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Literature summary for 3.4.22.61 extracted from

  • Calafat, M.; Larocca, L.; Roca, V.; Hauk, V.; Pregi, N.; Nesse, A.; Perez Leiros, C.
    Vasoactive intestinal peptide inhibits tumor necrosis factor-alpha-induced apoptotic events in acinar cells from non-obese diabetic mice submandibular glands (2009), Arthritis Res. Ther., 11, R53.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information PBOX-21/STI571 induces activation of caspase-8 leading to aopotosis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-IETD-fluoromethyl ketone a caspase-8 imhibitor, reduces the apoptotic rate in LAMA84 cells by about 50%, and prevents pro-caspase-8 cleavage Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-8 is a executioner or downstream caspase. Apoptosis induced by PBOX-21/STI571 results in activation of caspase-8, cleavage of PARP and Bcl-2, upregulation of the pro-apoptotic protein Bim and a downregulation of Bcr-Abl, important role for caspase-8 in the apoptotic pathway, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 cleavage to active caspase-8 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
K-562R cell STI571-resistant cells Mus musculus
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LAMA-84 cell
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 Mus musculus
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parotid acinar cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 is a executioner or downstream caspase. Apoptosis induced by PBOX-21/STI571 results in activation of caspase-8, cleavage of PARP and Bcl-2, upregulation of the pro-apoptotic protein Bim and a downregulation of Bcr-Abl, important role for caspase-8 in the apoptotic pathway, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
More caspases form a family of cysteine proteases Mus musculus