Literature summary for 3.4.22.61 extracted from

Johnke, R.M.; Smith, E.S.; Cariveau, M.J.; Evans, M.J.; Kilburn, J.M.; Bakken, N.T.; Nangami, G.N.
Radioprotection of murine gastrointestinal epithelium by interleukin-1alpha involves down-regulation of the apoptotic response (2009), Anticancer Res., 28, 3601-3607.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	active caspase-8 is upregulated under irradiation stress, and interleukin-1 does not prevent it when used in pretreatment, overview	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	interleukin-1 does not downregulate caspase-8 expression, but reduces apoptosis within the gastrointestinal crypts	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6 mice	-
Mus musculus C57BL/6	-	C57BL/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
jejunum	immunohistochemical determination of active caspases	Mus musculus	-

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Release 2023.1 (January 2023)