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Literature summary for 3.4.22.61 extracted from

  • Capper, D.; Gaiser, T.; Hartmann, C.; Habel, A.; Mueller, W.; Herold-Mende, C.; von Deimling, A.; Siegelin, M.D.
    Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation (2009), Acta Neuropathol., 117, 445-456.
    View publication on PubMed
Search for more literature for 3.4.22.61

Cloned(Commentary)

Cloned (Comment) Organism
determination of hypermethylation of CASP8 promoter in stem-cell-like glioma cells, whereas non-stem-cell-like glioma cells exhibit a non-methylated CASP8 promoter, expression analysis, overview Homo sapiens
gene CASP8, expression analysis, analysis of promoter methylation status, hypermethylation of the CASP8 promoter in stem-cell-like glioma cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation, reexpression of caspase-8 by 5-aza-2'-deoxycytidine is not suffient to restore TRAIL sensitivity in stem-cell-like glioma cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens stem-cell-like glioma cells are resistant to tumour necrosis factor -related apoptosis-inducing ligand, TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation ?
-
 ?
procaspase-3 + H2O Homo sapiens procaspase-8 activation in the death-inducing signalling complex, DISC, leads to cleavage of procaspase-3 and engagement of the cellular machinery associated with the type I extrinsic apoptotic pathway caspase-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
 gene CASP8
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is activated by cleavage Homo sapiens
proteolytic modification procaspase-8 is activated by cleavage to the active caspase-8 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell line NCH421K_SCG, NCH441_SCG, NCH421K_NSCG Homo sapiens
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glioblastoma cell line NCH441_SCG, NCH421K_SCG, NCH421K_NSCG Homo sapiens
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glioma cell stem-cell-like and non-stem-cell-like glioma cell Homo sapiens
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glioma cell stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information stem-cell-like glioma cells are resistant to tumour necrosis factor -related apoptosis-inducing ligand, TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation Homo sapiens ?
-
 ?
procaspase-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?
procaspase-3 + H2O procaspase-8 activation in the death-inducing signalling complex, DISC, leads to cleavage of procaspase-3 and engagement of the cellular machinery associated with the type I extrinsic apoptotic pathway Homo sapiens caspase-3 + ?
-
 ?