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Literature summary for 3.4.22.61 extracted from

  • Reinehr, R.; Sommerfeld, A.; Keitel, V.; Grether-Beck, S.; Hauessinger, D.
    Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes (2008), J. Biol. Chem., 283, 2211-2222.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus caspase 8 may not only play a role in initiating proapoptotic cascades through activation of downstream caspases but also by amplifying the amount of activated CD95 receptors ?
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 ?
additional information Rattus norvegicus CD95L initiates a rapid caspase 8-dependent endosomal acidification, which triggers ceramide-dependent ROS formation as an upstream event of trafficking of intracellularly stored CD95 to the plasma membrane. A rapid caspase 8 activation in response to CD95L signals to intracellularly stored CD95, which becomes activated and targeted to the plasma membrane ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase 8 may not only play a role in initiating proapoptotic cascades through activation of downstream caspases but also by amplifying the amount of activated CD95 receptors Rattus norvegicus ?
-
 ?
additional information CD95L initiates a rapid caspase 8-dependent endosomal acidification, which triggers ceramide-dependent ROS formation as an upstream event of trafficking of intracellularly stored CD95 to the plasma membrane. A rapid caspase 8 activation in response to CD95L signals to intracellularly stored CD95, which becomes activated and targeted to the plasma membrane Rattus norvegicus ?
-
 ?