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Literature summary for 3.4.22.61 extracted from
- Caspase-8 is scarcely silenced and its activity is well correlated with the anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand in gastric cancer cells (2005), Oncol. Rep., 14, 1249-1253.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | gastric cancer might be a good target of TRAIL therapy because the majority of tumor cells have intact caspase-8 expression. The anticancer efficacy may be predicted by the degree of caspase-8 activation after TRAIL treatment | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
fragment of caspase-8 resulting from cleavage, SDS-PAGE | Homo sapiens |
| 43000 | - |
fragment of caspase-8 resulting from cleavage, SDS-PAGE | Homo sapiens |
| 57000 | - |
monomer, full-length unactivated form, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q14790 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric cell line | OCUM-2M, OCUM-1, OCUM-8, OCUM-9, NUGC3, NIGC4, MKN45, MKN74, FU97, MKN7 | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-8 | - |
Homo sapiens |
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