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Literature summary for 3.4.22.61 extracted from

  • Fischer, U.; Stroh, C.; Schulze-Osthoff, K.
    Unique and overlapping substrate specificities of caspase-8 and caspase-10 (2006), Oncogene, 25, 152-159.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information dimerization Homo sapiens
Sodium citrate enhances activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CrmA
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

Purification (Commentary)

Purification (Comment) Organism
to near homogeneity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-IEPD-AMC + H2O 37°C Homo sapiens Ac-IEPD + AMC
-
?
BAP31 + H2O cleavage results in a proapoptotic p20 fragment Homo sapiens ?
-
?
Bcl-2 protein Bid + H2O cleavage results in a proapoptotic p15 tBid fragment Homo sapiens ?
-
?
Ca2+/calmodulin-dependent protein kinase-like kinase + H2O cleavage generates a 43 kDa C-terminal fragment and a small N-terminal fragment with proapoptotic activity Homo sapiens ?
-
?
p21-activated kinase 2 + H2O separates the N-terminal regulatory domain from the C-terminal catalytic domain Homo sapiens ?
-
?
procaspase-3 + H2O results in a p11 and p20 fragment Homo sapiens ?
-
?
receptor-indicating protein + H2O separates the N-terminal kinase from the C-terminal death domain Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer active form, SDS-PAGE Homo sapiens
monomer inactive form, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
caspase-8
-
Homo sapiens