Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Tumor necrosis factor alpha | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
c-FLIP | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14790 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | MCF7 A/Z breast adenocarcinoma cell defective for nuclear factor kappa-B activation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-IEPD-7-amido-4-methylcoumarin + H2O | 37°C | Homo sapiens | Ac-IEPD + 7-amino-4-methylcoumarin | - |
? | |
HER-2 + H2O | 37°C, HER-2 double mutant MT34, carrying the mutation D1125A/D837A | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, HER-2 double mutant MT35, carrying the mutation D1125A/D1087A, completely resistant to proteolysis | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, HER-2 double mutant MT36, carrying the mutation D1125A/D1115A | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, HER-2 mutant MT1, carrying the mutation D1012A | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, HER-2 mutant MT2, carrying the mutation D1019A | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, HER-2 mutant MT3, carrying the mutation D1125A, partially resistant to proteolysis | Homo sapiens | ? | - |
? | |
HER-2 + H2O | 37°C, wild-type HER-2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase-8 | - |
Homo sapiens |