Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Benoit, V.; Chariot, A.; Delacroix, L.; Deregowski, V.; Jacobs, N.; Merville, M.P.; Bours, V.
    Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression (2004), Cancer Res., 64, 2684-2691.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Tumor necrosis factor alpha
-
Homo sapiens

Application

Application Comment Organism
medicine HER-2 cleavage contributes to the TNF-alpha-induced apoptosis pathway Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
c-FLIP
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell MCF7 A/Z breast adenocarcinoma cell defective for nuclear factor kappa-B activation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-IEPD-7-amido-4-methylcoumarin + H2O 37°C Homo sapiens Ac-IEPD + 7-amino-4-methylcoumarin
-
?
HER-2 + H2O 37°C, HER-2 double mutant MT34, carrying the mutation D1125A/D837A Homo sapiens ?
-
?
HER-2 + H2O 37°C, HER-2 double mutant MT35, carrying the mutation D1125A/D1087A, completely resistant to proteolysis Homo sapiens ?
-
?
HER-2 + H2O 37°C, HER-2 double mutant MT36, carrying the mutation D1125A/D1115A Homo sapiens ?
-
?
HER-2 + H2O 37°C, HER-2 mutant MT1, carrying the mutation D1012A Homo sapiens ?
-
?
HER-2 + H2O 37°C, HER-2 mutant MT2, carrying the mutation D1019A Homo sapiens ?
-
?
HER-2 + H2O 37°C, HER-2 mutant MT3, carrying the mutation D1125A, partially resistant to proteolysis Homo sapiens ?
-
?
HER-2 + H2O 37°C, wild-type HER-2 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caspase-8
-
Homo sapiens