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Literature summary for 3.4.22.61 extracted from

  • Chang, D.W.; Xing, Z.; Capacio, V.L.; Peter, M.E.; Yang, X.
    Inerdimer processing mechanism of procaspase-8 activation (2003), EMBO J., 22, 4132-4142.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is activated through two cleavage events that proceed in a defined order to generate the large and small subunits of the mature protease. The dimerization of procaspase-8 produces enzymatically competent precursors through the stable homophilic interaction of the procaspase-8 protease domain. These dimers are also more susceptible to processing than individual procaspase-8 molecules, which leads to their cross-cleavage. The separation of the large and small subunits renders the region between the large subunit and prodomain susceptible to further cleavage Homo sapiens