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Literature summary for 3.4.22.61 extracted from

  • Muzio, M.; Salvesen, G.S.; Dixit, V.M.
    FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens (1997), J. Biol. Chem., 272, 2952-2956.
    View publication on PubMed
Search for more literature for 3.4.22.61

Inhibitors

Inhibitors Comment Organism Structure
cowpox serpin CrmA CrmA, a pox virus-encoded serpin attenuates the ability of FLICE to activate downstrean caspases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14790 recombinant enzyme expressed in Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FLICE2 + H2O
-
 Homo sapiens ?
-
 ?
LAP3 + H2O
-
 Homo sapiens ?
-
 ?
LAP6 + H2O
-
 Homo sapiens ?
-
 ?
additional information Mch2 and ICH1 are effectively cleaved only in the presence of native extract Homo sapiens ?
-
 ?
additional information CD95 and TNFR-1 death receptors initiate apoptosis by recruiting FLICE/MACH, which represents the apical triggering member of the protease death cascade and a target for the cell death inhibitor CrmA Homo sapiens ?
-
 ?
Tx + H2O
-
 Homo sapiens ?
-
 ?
Yama + H2O
-
 Homo sapiens ?
-
 ?