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Literature summary for 3.4.22.60 extracted from

  • Vance, N.R.; Gakhar, L.; Spies, M.A.
    Allosteric tuning of caspase-7 A fragment-based drug discovery approach (2017), Angew. Chem. Int. Ed. Engl., 56, 14443-14447 .
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor 2-[(2-acetylphenyl)sulfanyl]benzoic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-[(2-acetylphenyl)sulfanyl]benzoic acid noncompetitive Homo sapiens
[2-(phenylsulfanyl)phenyl]acetic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P55210
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.667
-
 [2-(phenylsulfanyl)phenyl]acetic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
5.5
-
 2-[(2-acetylphenyl)sulfanyl]benzoic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.637
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens [2-(phenylsulfanyl)phenyl]acetic acid
3.98
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[(2-acetylphenyl)sulfanyl]benzoic acid