Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-(4-methoxyphenyl)-4-(piperazin-1-yl)quinoline | 9% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
2-(4-methoxyphenyl)-N-[2-(morpholin-4-yl)ethyl]quinolin-4-amine | 4% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine | 17% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N'-[2-(4-ethylphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine | 26% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylethane-1,2-diamine | 123% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N'-[2-(4-methoxyphenyl)quinolin-4-yl]-N,N-dimethylpropane-1,3-diamine | 117% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N,N-diethyl-N'-[2-(4-ethylphenyl)quinolin-4-yl]propane-1,3-diamine | 24% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens | |
N,N-diethyl-N'-[2-(4-methoxyphenyl)quinolin-4-yl]propane-1,3-diamine | 124% stimulation of caspase-7 cleavage of TDP-43 at 0.01 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
PARP + H2O | Homo sapiens | - |
? | - |
? | |
TAR DNA binding protein 43 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H4 cell | - |
Homo sapiens | - |
neuroglioma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-DEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-DEVD + 7-amino-4-methylcoumarin | - |
? | |
PARP + H2O | - |
Homo sapiens | ? | - |
? | |
TAR DNA binding protein 43 + H2O | - |
Homo sapiens | ? | - |
? |