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Literature summary for 3.4.22.60 extracted from

  • Edelmann, B.; Bertsch, U.; Tchikov, V.; Winoto-Morbach, S.; Perrotta, C.; Jakob, M.; Adam-Klages, S.; Kabelitz, D.; Schuetze, S.
    Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes (2011), EMBO J., 30, 379-394.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information deletion of caspase-7 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information active caspase-7 colocalizes with internalized TNF-R1 receptosomes, molecular components of a potential signalling cascade from TNF-R1 to A-SMase via caspase-7 actually localize in the same subcellular compartment. Direct association of caspase-7 and A-SMase within TNF receptosomes Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE Homo sapiens
31000
-
1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acid sphingomyelinase + H2O Homo sapiens caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of procaspase-7 of 35 kDa to the active forms of 31 and 20 kDa, TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
JURKAT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acid sphingomyelinase + H2O caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes Homo sapiens ?
-
?
acid sphingomyelinase + H2O A-SMase, caspase-7 activates acid sphingomyelinase induced by TNF, overview Homo sapiens ?
-
?
acid sphingomyelinase + H2O acid sphingomyelinase, i.e. A-SMase, free or as fusion protein A-SMase-EGFP, a glycosylated protein, caspase-7 activates A-SMase induced by TNF, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer 1 * 31000 + 1 * 20000, active caspase-7, SDS-PAGE Homo sapiens
monomer 1 * 35000-37000, procaspase-7, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
caspase-7
-
Homo sapiens

General Information

General Information Comment Organism
malfunction deletion of caspase-7 inhibits TNF-induced cleavage and activation of A-SMase Homo sapiens
additional information active caspase-7 colocalizes with internalized TNF-R1 receptosomes. TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes Homo sapiens