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Literature summary for 3.4.22.60 extracted from

  • Akhter, A.; Gavrilin, M.A.; Frantz, L.; Washington, S.; Ditty, C.; Limoli, D.; Day, C.; Sarkar, A.; Newland, C.; Butchar, J.; Marsh, C.B.; Wewers, M.D.; Tridandapani, S.; Kanneganti, T.D.; Amer, A.O.
    Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection (2009), PLoS Pathog., 5, e1000361.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information activation of caspase-7 in macrophages by cleavage through caspase-1 is mediated by bacterial flagellin and absolutely requires a functional host proteins Nlrc4 and Naip5 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of caspase-7 in caspase-7-deficient mouse macrophages Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication, while wild-type mouse strains are restrictive to Legionella pneumophila infection Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages ?
-
 ?
additional information Mus musculus C57BL/6 intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C57BL/6 mice
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Mus musculus C57BL/6
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 C57BL/6 mice
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-7 is activated by caspase-1 cleavage to caspase-7 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage bone marrow macrophages prepared from femurs of five to eight-week-old mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages Mus musculus ?
-
 ?
additional information intracellular pathogen Legionella pneumophila strain Lp02 infection of murine macrophages leads to caspase-7 activation downstream of the Nlrc4 inflammasome requiring activation by caspase-1, overview. Caspase-1-dependent caspase-7 activation contributes to Legionella pneumophila phagosome maturation in macrophages Mus musculus C57BL/6 ?
-
 ?