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Literature summary for 3.4.22.60 extracted from

  • Frydrych, I.; Mlejnek, P.
    Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli (2008), J. Cell. Biochem., 105, 1501-1506.
    View publication on PubMed
Search for more literature for 3.4.22.60

Activating Compound

Activating Compound Comment Organism Structure
N6-(2-isopentenyl)adenosine highly induces enzyme activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-alpha-tosyl-L-lysyl-chloromethylketone i.e. TLCK, substantially inhibits caspase-7 enzymatic DEVDase activity, but does not affect caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases Homo sapiens
N-tosyl-L-phenylalanyl-chloromethylketone i.e. TPCK, enhances caspase-7 processing although it substantially inhibits caspase-7 enzymatic DEVDase activity in HL-60 cells exposed to various cell death inducing stimuli, irreversibly alkylates cysteine residues of the active site of cysteine proteases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O a caspase-3 substrate Homo sapiens Ac-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin
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 ?
additional information inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DEVDase
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 Homo sapiens