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Literature summary for 3.4.22.60 extracted from

  • Jang, M.; Park, B.C.; Lee, A.Y.; Na, K.S.; Kang, S.; Bae, K.H.; Myung, P.K.; Chung, B.C.; Cho, S.; Lee, d.o.H.; Park, S.G.
    Caspase-7 mediated cleavage of proteasome subunits during apoptosis (2007), Biochem. Biophys. Res. Commun., 363, 388-394.
    View publication on PubMed
Search for more literature for 3.4.22.60

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethyl ketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
26S proteasome subunit + H2O Homo sapiens during apoptosis, the activated caspase-7 directly cleaves certain subunits of 26S proteasomes, which then result in a decline in the proteasomal activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
26S protease regulatory subunit 4 + H2O SwissProt: P62192 M Homo sapiens ?
-
 ?
26S protease regulatory subunit 7 + H2O SwissProt: P35998 Homo sapiens ?
-
 ?
26S proteasome subunit + H2O during apoptosis, the activated caspase-7 directly cleaves certain subunits of 26S proteasomes, which then result in a decline in the proteasomal activity Homo sapiens ?
-
 ?
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
-
 Homo sapiens acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
 ?
proteasome activator complex subunit 1 + H2O SwissProt: Q06323 Homo sapiens ?
-
 ?
proteasome subunit alpha type-1 + H2O SwissProt: P25786 Homo sapiens ?
-
 ?
proteasome subunit alpha type-2 + H2O SwissProt: P25787 Homo sapiens ?
-
 ?
proteasome subunit alpha type-3 + H2O SwissProt: P25788 Homo sapiens ?
-
 ?
proteasome subunit alpha type-6 + H2O SwissProt: P60900 Homo sapiens ?
-
 ?