Literature summary for 3.4.22.60 extracted from

Goode, D.R.; Sharma, A.K.; Hergenrother, P.J.
Using peptidic inhibitors to systematically probe the S1 site of caspase-3 and caspase-7 (2005), Org. Lett., 7, 3529-3532.

Search for more literature for 3.4.22.60

Application

Application	Comment	Organism
medicine	substitution in the P1' position could be used in synergy with other elements to obtain highly potent and isozyme-selective caspase inhibitors	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
AC-DEVD-aldehyde inhibitor	-	Homo sapiens
ketonic peptides	in the straight-chain aliphatic series, increasing inhibition with increasing chain length, for the unsubstituted aromatic P1' inhibitors increasing potency with decreasing linker length	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-DEVD-p-nitroanilide + H2O	-	Homo sapiens	p-nitroaniline + Ac-DEVD	-	?

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Release 2023.1 (January 2023)