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Literature summary for 3.4.22.60 extracted from

  • Ohara, M.; Hayashi, T.; Kusunoki, Y.; Miyauchi, M.; Takata, T.; Sugai, M.
    Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines (2004), Infect. Immun., 72, 871-879.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cytolethal distending toxin from Actinobacillus actinomycetemcomitans Homo sapiens

Application

Application Comment Organism
medicine Actinobacillus actinomycetemcomitans cytolethal distending toxin acts as an immunosuppressive factor, it possesses the ability to induce human T-cell apoptosis through activation of caspase-7 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ac-DEVD-CHO
-
Homo sapiens
AC-DQTD-CHO
-
Homo sapiens
Ac-Val-Ala-Asp-fluoromethylketone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-
MOLT-4 cell
-
Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-DEVD-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Ac-DEVD + 7-amino-4-methylcoumarin
-
?
Ac-DQTD-7-amido-4-methylcoumarin + H2O
-
Homo sapiens Ac-DQTD + 7-amino-4-methylcoumarin
-
?