Literature summary for 3.4.22.60 extracted from

Yacobi, K.; Wojtowicz, A.; Tsafriri, A.; Gross, A.
Gonadotropins enhance caspase-3 and -7 activity and apoptosis in the theca-interstitial cells of rat preovulatory follicles in culture (2004), Endocrinology, 145, 1943-1951.

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Activating Compound

Activating Compound	Comment	Organism	Structure
FSH	antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells	Rattus norvegicus
gonadotropins	increases caspase-7 activity in both theca-interstitial cells and granulosa cells	Rattus norvegicus
LH	antiapoptotic effect on granulosa cells and a proapoptotic effect on theca-interstitial cells	Rattus norvegicus
additional information	caspase-7 activity not increased by IGF-I	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Z-Val-Ala-Asp-fluoromethylketone	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	immature female Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
granulosa cell	-	Rattus norvegicus	-
additional information	theca-interstitial cells, preovulatory follicles	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin	-	Rattus norvegicus	acetyl-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)