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Literature summary for 3.4.22.60 extracted from
- Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis (2005), Apoptosis, 10, 643-650.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| etoposide | procaspase-7 cleavage (= activation of caspase-7), which is abrogated in cells with ectopically expressed p53 | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | low-dosage topoisomerase II inhibitor etoposide effectively inhibits proliferation rate | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DEVD-CHO | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | NCI-H358 cell | Homo sapiens | - |
| NCI-H1299 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DEVD-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | DEVD + 7-amino-4-methylcoumarin | - |
? | |
| PARP + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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