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Literature summary for 3.4.22.60 extracted from
- Inhibition of human caspases by peptide-based and macromolecular inhibitors (1998), J. Biol. Chem., 273, 32608-32613.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-AEVD-aldehyde | - |
Homo sapiens |  |
| acetyl-DEVD-aldehyde | - |
Homo sapiens | |
| acetyl-IETD-aldehyde | - |
Homo sapiens | |
| benzyloxycarbonyl-VAD-fluoromethylketone | t1/2 at 0.001 mM is 98 s | Homo sapiens | |
| additional information | KI-values higher than 0.01 mM are determined for acetyl-WEHD-aldehyde and acetyl-YVAD-aldehyde and cowpox serin CrmA | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000016 | - |
acetyl-DEVD-aldehyde | pH 7.5, 25°C | Homo sapiens | |
| 0.000425 | - |
acetyl-AEVD-aldehyde | pH 7.5, 25°C | Homo sapiens | |
| 0.00328 | - |
acetyl-IETD-aldehyde | pH 7.5, 25°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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