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Literature summary for 3.4.22.56 extracted from

  • Dick, S.A.; Chang, N.C.; Dumont, N.A.; Bell, R.A.; Putinski, C.; Kawabe, Y.; Litchfield, D.W.; Rudnicki, M.A.; Megeney, L.A.
    Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells (2015), Proc. Natl. Acad. Sci. USA, 112, E5246-E5252 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of caspase 3 activity leads to a profound disruption in skeletal muscle regeneration with an accumulation of satellite cells within the niche Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
transcription factor Pax7 + H2O Mus musculus compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7. Continued expression of this protein inhibits the myoblast differentiation program. Caspase 3 cleavage inactivation of Pax7 is a crucial step for terminating the self-renewal process ?
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Organism

Organism UniProt Comment Textmining
Mus musculus P70677
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Source Tissue

Source Tissue Comment Organism Textmining
muscle fibre
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
transcription factor Pax7 + H2O
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 Mus musculus ?
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 ?
transcription factor Pax7 + H2O compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7. Continued expression of this protein inhibits the myoblast differentiation program. Caspase 3 cleavage inactivation of Pax7 is a crucial step for terminating the self-renewal process Mus musculus ?
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 ?

General Information

General Information Comment Organism
physiological function compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7. Continued expression of this protein inhibits the myoblast differentiation program. Caspase 3 cleavage inactivation of Pax7 is a crucial step for terminating the self-renewal process Mus musculus