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Literature summary for 3.4.22.56 extracted from

  • Li, Z.; Pan, Y.; Zhong, W.; Zhu, Y.; Zhao, Y.; Li, L.; Liu, W.; Zhou, H.; Yang, C.
    Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors (2014), Bioorg. Med. Chem., 22, 6735-6745.
    View publication on PubMed
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
1-(3-oxo-1,2-benzothiazol-2(3H)-yl)-4-(thiophen-2-yl)butane-1,4-dione
-
 Homo sapiens
2-(1,3-dihydro-2-benzofuran-5-ylacetyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(3-phenylpropanoyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(4-phenylbutanoyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(5-phenylpentanoyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(biphenyl-4-ylacetyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(naphthalen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(phenylacetyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-(thiophen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(2-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(2-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(2-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(2-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(3,4-dichlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(3-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(3-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(3-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(3-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(4-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(4-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(4-hydroxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(4-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[(4-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(2-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(2-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(2-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(3-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(3-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(3-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(4-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(4-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[3-(4-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one most potent inhibitor Homo sapiens
2-[3-(4-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-(4-methoxyphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-(4-methylphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
2-[4-(thiophen-2-yl)butanoyl]-1,2-benzothiazol-3(2H)-one
-
 Homo sapiens
N-acetyl-DEVD-CHO
-
 Homo sapiens
N-[4-(morpholin-4-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-DEVD-7-amido-4-methylcoumarin + H2O Homo sapiens
-
 N-acetyl-DEVD + 7-amino-4-methylcoumarin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-acetyl-DEVD + 7-amino-4-methylcoumarin
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000349
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(3-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0000473
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(2-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0000497
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(4-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0000569
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(4-chlorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0000877
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(3-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.000095
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(3-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0001063
-
 at pH 7.5, temperature not specified in the publication Homo sapiens N-[4-(morpholin-4-yl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide
0.0001084
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(3-phenylpropanoyl)-1,2-benzothiazol-3(2H)-one
0.0001116
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(4-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.000119
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(4-methylphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0001266
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[4-(thiophen-2-yl)butanoyl]-1,2-benzothiazol-3(2H)-one
0.0001297
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(2-fluorophenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0001357
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[3-(2-methoxyphenyl)propanoyl]-1,2-benzothiazol-3(2H)-one
0.0001406
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(biphenyl-4-ylacetyl)-1,2-benzothiazol-3(2H)-one
0.0001816
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(4-phenylbutanoyl)-1,2-benzothiazol-3(2H)-one
0.0001857
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(2-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0001999
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(2-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0002143
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(4-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0002151
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(4-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0002186
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(2-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0002217
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(1,3-dihydro-2-benzofuran-5-ylacetyl)-1,2-benzothiazol-3(2H)-one
0.000245
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 1-(3-oxo-1,2-benzothiazol-2(3H)-yl)-4-(thiophen-2-yl)butane-1,4-dione
0.0002646
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(naphthalen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
0.0002659
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[4-(4-methylphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
0.0002719
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(3-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0002921
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(phenylacetyl)-1,2-benzothiazol-3(2H)-one
0.0003061
-
 at pH 7.5,temperature not specified in the publication Homo sapiens 2-(5-phenylpentanoyl)-1,2-benzothiazol-3(2H)-one
0.0003263
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(4-hydroxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0003392
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(3-methylphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0003897
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[4-(4-methoxyphenyl)butanoyl]-1,2-benzothiazol-3(2H)-one
0.000548
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(3-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0006543
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(3,4-dichlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.001196
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(4-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.001344
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(4-methoxyphenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.001926
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(2-chlorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.008985
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-[(3-fluorophenyl)acetyl]-1,2-benzothiazol-3(2H)-one
0.0322
-
 at pH 7.5, temperature not specified in the publication Homo sapiens 2-(thiophen-2-ylacetyl)-1,2-benzothiazol-3(2H)-one
0.0757
-
 at pH 7.5, temperature not specified in the publication Homo sapiens N-acetyl-DEVD-CHO