Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Transetta (DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-benzisothiazol-3-one | - |
Homo sapiens | |
2-(2-phenylethyl)-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-(4-fluorobenzyl)-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-(4-methoxybenzyl)-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-(prop-2-en-1-yl)-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-benzyl-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-ethyl-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-methyl-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-phenyl-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
2-[3-(trifluoromethyl)phenyl]-1,2-benzothiazol-3(2H)-one | - |
Homo sapiens | |
3-oxo-N-(1-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
3-oxo-N-(2-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
3-oxo-N-phenyl-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(2-nitrophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(3-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(3-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(3-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(3-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(3-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-iodophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-acetyl-DEVD-CHO | - |
Homo sapiens | |
N-benzyl-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-ethyl-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens | |
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA agarose column chromatography and Resource Q column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-LDEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | N-acetyl-LDEVD + 7-amino-4-methylcoumarin | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000002 | - |
at pH 7.5 and 22°C | Homo sapiens | N-acetyl-DEVD-CHO | |
0.000031 | - |
at pH 7.5 and 22°C | Homo sapiens | 3-oxo-N-(2-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide | |
0.00004 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(4-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000074 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(3-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000076 | - |
at pH 7.5 and 22°C | Homo sapiens | 3-oxo-N-phenyl-1,2-benzothiazole-2(3H)-carboxamide | |
0.000085 | - |
at pH 7.5 and 22°C | Homo sapiens | 3-oxo-N-(1-phenylethyl)-1,2-benzothiazole-2(3H)-carboxamide | |
0.000086 | - |
at pH 7.5 and 22°C | Homo sapiens | N-benzyl-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000088 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-methoxybenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000115 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(4-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000206 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000241 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(3-fluorobenzyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.000438 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(3-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.0004657 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one | |
0.0005328 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-phenyl-1,2-benzothiazol-3(2H)-one | |
0.000593 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(4-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.001167 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(3-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.003071 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(4-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.004167 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.008093 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.009628 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(3-bromophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.009823 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-nitrophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.01071 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(4-methoxyphenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.0108 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-benzyl-1,2-benzothiazol-3(2H)-one | |
0.01209 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-(4-methoxybenzyl)-1,2-benzothiazol-3(2H)-one | |
0.01364 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-(4-fluorobenzyl)-1,2-benzothiazol-3(2H)-one | |
0.01627 | - |
at pH 7.5 and 22°C | Homo sapiens | N-(2-fluorophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.01855 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-(2-phenylethyl)-1,2-benzothiazol-3(2H)-one | |
0.02205 | - |
at pH 7.5 and 22°C | Homo sapiens | N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-1,2-benzothiazole-2(3H)-carboxamide | |
0.02272 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-(prop-2-en-1-yl)-1,2-benzothiazol-3(2H)-one | |
0.04239 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-methyl-1,2-benzothiazol-3(2H)-one | |
0.04674 | - |
at pH 7.5 and 22°C | Homo sapiens | 1,2-benzisothiazol-3-one | |
0.09124 | - |
at pH 7.5 and 22°C | Homo sapiens | 2-ethyl-1,2-benzothiazol-3(2H)-one | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 22°C | Homo sapiens | N-(4-iodophenyl)-3-oxo-1,2-benzothiazole-2(3H)-carboxamide |