Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation dynamics of caspase 3. Caspase 3 is activated rapidly. During H2O2-induced apoptosis, caspase 3 is activated directly through caspase 8 and not through the mitochondria-dependent caspase 9 activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Z-LEHD-fluoromethylketone, a caspase 9 specific inhibitor, does not affect caspase 3 activation | Homo sapiens | |
Z-DEVD-fluoromethylketone | a caspase 3 specific inhibitor | Homo sapiens | |
Z-IETD-fluoromethylketone | a caspase 8 specific inhibitor, delays the activation of caspase 3 and caspase 9 significantly | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-3 cleaves the the DEVD sequence | Homo sapiens | ? | - |
? | |
N-acetyl-DEVD-4-trifluoromethylcoumarin 7-amide + H2O | - |
Homo sapiens | N-acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase 3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase 8 is an initiator caspase for caspase 3 during H2O2-induced apoptosis. During H2O2-induced apoptosis, caspase 3 is activated directly through caspase 8 and not through the mitochondriadependent caspase 9 activation | Homo sapiens |