Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TNF-alpha induces the enzyme activation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | constitutive caspase-3 is one of the downstream effectors of TNF-alpha receptor-1 binding, that increases in parallel with the loss of CD28 in long-term T lymphocyte cultures, but this effect is blunted in the presence of the TNF-alpha inhibitors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | CD8+CD28- T lymphocytes show significantly higher levels of caspase-3 compared with their CD28+ counterparts | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | constitutive caspase-3 is one of the downstream effectors of TNF-alpha receptor-1 binding, that increases in parallel with the loss of CD28 in long-term T lymphocyte cultures, but this effect is blunted in the presence of the TNF-alpha inhibitors | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |