Literature summary for 3.4.22.56 extracted from

Frydrych, I.; Mlejnek, P.
Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli (2008), J. Cell. Biochem., 105, 1501-1506.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Ac-DEVD-CHO	a caspase-3 inhibitor	Homo sapiens
additional information	processing of caspase-3 is affected only negligibly in cells treated with etoposide or N6-(2-isopentenyl)adenosine	Homo sapiens
N-alpha-tosyl-L-lysinyl-chloromethylketone	TLCK, a serine protease inhibitor and potent but nonspecific inhibitor of mature caspases, TLCK has no or only slight effect on caspase-3 processing, but TLCK substantially inhibits caspase-3 enzymatic DEVDase activity, but does not prevent cells from death	Homo sapiens
N-tosyl-L-phenylalaninyl-chloromethylketone	TPCK, a serine protease inhibitor and potent but nonspecific inhibitor of mature caspases, enhances caspase-3 processing although it substantially inhibits caspase-3 enzymatic DEVDase activity in HL-60 cells exposed to various cell death inducing stimuli, but does not prevent cells from death, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-DEVD-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Ac-DEVD + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
DEVDase	-	Homo sapiens

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Release 2023.1 (January 2023)