Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-carbobenzyloxy-DEVD-fluoromethyl ketone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein phosphatase-1 inhibitor-3 + H2O | Homo sapiens | the substrate is an in vivo target of caspase-3 and participates in the apoptotic response to induction by actinomycin D, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
additional information | the MCF-7 human breast carcinoma cell line is caspase-3-deficient because of the deletion of exon 3 in the caspase-3 gene | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein phosphatase-1 inhibitor-3 + H2O | the substrate is an in vivo target of caspase-3 and participates in the apoptotic response to induction by actinomycin D, overview | Homo sapiens | ? | - |
? | |
protein phosphatase-1 inhibitor-3 + H2O | recombinant His6-tagged substrate protein expressed in Escherichia coli, substrate mutant D49A is not cleaved by caspase-3 | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |