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Literature summary for 3.4.22.56 extracted from

  • Huang, H.S.; Lee, E.Y.
    Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response (2008), J. Biol. Chem., 283, 18135-18146.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-DEVD-fluoromethyl ketone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein phosphatase-1 inhibitor-3 + H2O Homo sapiens the substrate is an in vivo target of caspase-3 and participates in the apoptotic response to induction by actinomycin D, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-
additional information the MCF-7 human breast carcinoma cell line is caspase-3-deficient because of the deletion of exon 3 in the caspase-3 gene Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein phosphatase-1 inhibitor-3 + H2O the substrate is an in vivo target of caspase-3 and participates in the apoptotic response to induction by actinomycin D, overview Homo sapiens ?
-
?
protein phosphatase-1 inhibitor-3 + H2O recombinant His6-tagged substrate protein expressed in Escherichia coli, substrate mutant D49A is not cleaved by caspase-3 Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens