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Literature summary for 3.4.22.56 extracted from

  • Epple, H.J.; Schneider, T.; Troeger, H.; Kunkel, D.; Allers, K.; Moos, V.; Amasheh, M.; Loddenkemper, C.; Fromm, M.; Zeitz, M.; Schulzke, J.D.
    Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients (2009), Gut, 58, 220-227.
    View publication on PubMed

Application

Application Comment Organism
diagnostics caspase-3 activity is a marker for apoptosis in gut epithelium, leading to impairment of the gastrointestinal mucosal barrier, that contributes to progression of HIV infection, immunohistochemical staining of cleaved caspase-3, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens active caspase-3 is involved in apoptosis in epithelial cells of the intestine ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-3 is activated by cleavage to caspase-3 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell active cleaved caspase-3 in epithelial cells of the intestine, quantitative immunohistochemical staining, overview Homo sapiens
-
intestine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information active caspase-3 is involved in apoptosis in epithelial cells of the intestine Homo sapiens ?
-
?