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Literature summary for 3.4.22.56 extracted from

  • Goebel, D.J.
    Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons (2009), Brain Res., 1256, 190-204.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information N-methyl-D-aspartate induces caspase-3 activation, mechanism, overview, autocamtide-2-related inhibitory peptide attenuates caspase-3 activation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus N-methyl-D-aspartate induces the activation of caspase-3 and the caspase-3-dependent apoptotic pathway, the activation is prevented by the autocamtide-2-related inhibitory peptide, overview. Blockade of calcium/calmodulin-dependent protein kinase II-alpha activity prevents N-methyl-D-aspartate-induced caspase-3 activation and provides significant neuroprotection against N-methyl-D-aspartate-induced ganglion cell loss in a retina toxicity model ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
ganglion retinal Rattus norvegicus
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retina
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information N-methyl-D-aspartate induces the activation of caspase-3 and the caspase-3-dependent apoptotic pathway, the activation is prevented by the autocamtide-2-related inhibitory peptide, overview. Blockade of calcium/calmodulin-dependent protein kinase II-alpha activity prevents N-methyl-D-aspartate-induced caspase-3 activation and provides significant neuroprotection against N-methyl-D-aspartate-induced ganglion cell loss in a retina toxicity model Rattus norvegicus ?
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