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Literature summary for 3.4.22.56 extracted from

  • van Raam, B.J.; Drewniak, A.; Groenewold, V.; van den Berg, T.K.; Kuijpers, T.W.
    Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3 (2008), Blood, 112, 2046-2054.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-VAD
-
 Homo sapiens
G-CSF a caspase-3 inhibitor that also inhibits the steady increase in cytosolic free Ca2 during neutrophil aging, which is essential for apoptosis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification during spontaneous neutrophil apoptosis caspase-3 are rapidly activated Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-
granulocyte
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-7-amido-4-fluoromethylcoumarin + H2O
-
 Homo sapiens DEVD + 7-amino-4-fluoromethylcoumarin
-
 ?
IETD-7-amido-4-fluoromethylcoumarin + H2O
-
 Homo sapiens IETD + 7-amino-4-fluoromethylcoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens