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Literature summary for 3.4.22.56 extracted from

  • Colantonio, P.; Leboffe, L.; Bolli, A.; Marino, M.; Ascenzi, P.; Luisi, G.
    Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation (2008), Biochem. Biophys. Res. Commun., 377, 757-762.
    View publication on PubMed
Search for more literature for 3.4.22.56

Inhibitors

Inhibitors Comment Organism Structure
Ac-Asp-Glu-Val-Asp-H the molecule can be truncated to Z-tLeu-Asp-H retaining nanomolar inhibitory activity in vitro and displaying action in whole cells, overview Homo sapiens
additional information inhibitor synthesis, overview Homo sapiens
N-benxylozycarbonyl-tLeu-Asp a peptide adehyde, competitively inhibits human caspase-3 activity in vitro. Z-tLeu-Asp-H impairs apoptosis in human DLD-1 colon adenocarcinoma cells without affecting caspase-8, in vivo effects, overview Homo sapiens
N-benxylozycarbonyl-tLeu-Val-Asp a peptide adehyde, competitively inhibits human caspase-3 activity in vitro Homo sapiens
N-benxylozycarbonyl-Val-tLeu-Asp a peptide adehyde, competitively inhibits human caspase-3 activity in vitro Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000036
-
 N-benxylozycarbonyl-tLeu-Asp pH 7.4, 25°C Homo sapiens
0.0000182
-
 N-benxylozycarbonyl-tLeu-Val-Asp pH 7.4, 25°C Homo sapiens
0.000109
-
 N-benxylozycarbonyl-Val-tLeu-Asp pH 7.4, 25°C Homo sapiens