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Literature summary for 3.4.22.56 extracted from

  • Dharmapatni, A.A.; Smith, M.D.; Findlay, D.M.; Holding, C.A.; Evdokiou, A.; Ahern, M.J.; Weedon, H.; Chen, P.; Screaton, G.; Xu, X.N.; Haynes, D.R.
    Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium (2009), Arthritis Res. Ther., 11, R13.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
inhibitor of apoptosis protein IAP, the family members block effector caspase-3 further downstream, which potentially inhibits apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens TRAIL and TRAIL death receptors form a complex, which transmits an apoptotic signal via the Fas associated death domain leading to activation of caspase-8 or other initiator caspases, which in turn activate downstream caspases, such as caspase-3, 9, 6 and 7, that cause cell death, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-3 is activated by cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
synovial tissue from healthy and arthritic individuals Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TRAIL and TRAIL death receptors form a complex, which transmits an apoptotic signal via the Fas associated death domain leading to activation of caspase-8 or other initiator caspases, which in turn activate downstream caspases, such as caspase-3, 9, 6 and 7, that cause cell death, overview Homo sapiens ?
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