Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Ideo, A.; Hashimoto, K.; Shimada, J.; Kawase, M.; Sakagami, H.
    Type of cell death induced by alpha-trifluoromethyl acyloins in oral squamous cell carcinoma (2009), Anticancer Res., 29, 175-181.
    View publication on PubMed
Search for more literature for 3.4.22.56

Activating Compound

Activating Compound Comment Organism Structure
actinomycin D significantly activates caspase-3 Homo sapiens
additional information alpha-trifluoromethyl acyloins TF2 and TF3, i.e. CF3CH(OH)COPh and CF3CH(OH)COCH2Ph, fail to activate caspase-3 in both HSC-2 and HSC-4 cells during 4-24 hours treatment, however, TF2 and TF3 induce apoptotic cell death in human submandibular gland carcinoma cells Homo sapiens

Application

Application Comment Organism
diagnostics caspase-3 can act as apoptosis marker Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HSC-2 cell a oral squamous cell carcinoma cell line Homo sapiens
-
HSC-4 cell a oral squamous cell carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Asp-Glu-Val-Asp-4-nitroanilide + H2O
-
 Homo sapiens Asp-Glu-Val-Asp + 4-nitroaniline
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens