Application | Comment | Organism |
---|---|---|
medicine | geldanamycin limits caspase-3 expression and protects from organ injury by suppressing inducible nitric oxide synthase expression and apoptosome formation. Geldanamycin, therefore may prove useful as an adjuvant in fluids used to treat patients suffering blood loss | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity | Mus musculus | - |
heart | geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity | Mus musculus | - |
jejunum | geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity | Mus musculus | - |
kidney | geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity | Mus musculus | - |
lung | geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O | - |
Mus musculus | acetyl-Asp-Glu-Val-Asp + p-nitroaniline | - |
? |