Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.56 extracted from

  • Kiang, J.G.; Bowman, P.D.; Lu, X.; Li, Y.; Wu, B.W.; Loh, H.H.; Tsen, K.T.; Tsokos, G.C.
    Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase (2007), J. Appl. Physiol., 103, 1045-1055.
    View publication on PubMed

Application

Application Comment Organism
medicine geldanamycin limits caspase-3 expression and protects from organ injury by suppressing inducible nitric oxide synthase expression and apoptosome formation. Geldanamycin, therefore may prove useful as an adjuvant in fluids used to treat patients suffering blood loss Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity Mus musculus
-
heart geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity Mus musculus
-
jejunum geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity Mus musculus
-
kidney geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity Mus musculus
-
lung geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
-
Mus musculus acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
?