Literature summary for 3.4.22.56 extracted from

Burkhardt, B.R.; Greene, S.R.; White, P.; Wong, R.K.; Brestelli, J.E.; Yang, J.; Robert, C.E.; Brusko, T.M.; Wasserfall, C.H.; Wu, J.; Atkinson, M.A.; Gao, Z.; Kaestner, K.H.; Wolf, B.A.
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21) (2006), Gene, 369, 134-141.

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Activating Compound

Activating Compound	Comment	Organism	Structure
pancreatic derived factor	islet specific cytokine, capable of inducing apoptosis, increases levels of cleaved CASP3 in beta-TC3 cells	Mus musculus

Application

Application	Comment	Organism
medicine	PANDER-induced downregulation of cyclin-dependent kinase inhibitor 1A expression coupled with induced CASP3-activation may serve a central role in islet cell death and offers further insight into the mechanisms of cytokine-induced beta-cell apoptosis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus	-	C57B1/6	-
Mus musculus C57/BL6	-	C57B1/6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
beta-TC3 cell	insulinoma cell, treatment with islet-specific cytokine pancreatic derived factor results in elevated enzyme levels which abrogates expression of cyclin-dependent kinase inhibitor 1A	Mus musculus	-
additional information	beta-TC3 murine inulinoma cells	Mus musculus	-
pancreas	islet cell	Mus musculus	-
pancreatic islet	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CASP3	-	Mus musculus

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Release 2023.1 (January 2023)