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Literature summary for 3.4.22.56 extracted from

  • Pirhonen, J.; Sareneva, T.; Julkunen, I.; Matikainen, S.
    Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation (2001), Eur. J. Immunol., 31, 726-733.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-DEVD-aldehyde
-
Homo sapiens
acetyl-YVAD-aldehyde
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-18 + H2O Homo sapiens virus infection by influenzy A or Sendai virus induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation IL18 + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification inactive 32000 Da proform of caspase-3 is basally expressed in macrophages, virus infection induces the cleavage of procaspase into the mature 17000 Da form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
macrophage inactive 32000 Da proform of caspase-3 is basally expressed in macrophages, virus infection induces the cleavage of procaspase into the mature 17000 Da form Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-interleukin-18 + H2O
-
Homo sapiens interleukin-18 + ?
-
?
pro-interleukin-18 + H2O virus infection by influenzy A or Sendai virus induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation Homo sapiens IL18 + ?
-
?