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Literature summary for 3.4.22.56 extracted from

  • Mittl, P.R.E.; di Marco, S.; Krebs, J.F.; et al.
    Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone (1997), J. Biol. Chem., 272, 6539-6547.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of recombinant enzyme in complex with acetyl-Asp-Val-Ala-Asp fluoromethyl ketone, hanging and sitting drop vapor diffusion method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetyl-DEVD-aldehyde
-
Homo sapiens
acetyl-YVAD-aldehyde
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0086
-
acetyl-DEVD-7-amido-4-methylcoumarin pH 7.5 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
-
Homo sapiens acetyl-DEVD + 7-amino-4-methylcoumarin
-
?

Subunits

Subunits Comment Organism
More two bands of 12000 Da and 17000 Da are detected by SDS-PAGE Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0008
-
acetyl-DEVD-aldehyde pH 7.5 Homo sapiens
0.012
-
acetyl-YVAD-aldehyde pH 7.5 Homo sapiens