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Literature summary for 3.4.22.55 extracted from

  • Terry, M.; Arya, R.; Mukhopadhyay, A.; Berrett, K.; Clair, P.; Witt, B.; Salama, M.; Bhutkar, A.; Oliver, T.
    Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo (2015), Cell Death Differ., 22, 719-730 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Mdm2 protein + H2O Homo sapiens caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42575
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung adenocarcinoma cell caspase-2 levels are significantly reduced in human lung adenocarcinoma with wild-type p53 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mdm2 protein + H2O
-
 Homo sapiens ?
-
 ?
Mdm2 protein + H2O caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
malfunction loss of caspase-2 leads to enhanced tumor proliferation and progression Homo sapiens
physiological function caspase-2 functions as a tumor suppressor in Kras-driven lung cancer in vivo. Caspase-2 cleaves and inhibits Mdm2 and thereby promotes the stability of the tumor-suppressor p53 Homo sapiens