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Literature summary for 3.4.22.55 extracted from

  • Olsson, M.; Forsberg, J.; Zhivotovsky, B.
    Caspase-2: the reinvented enzyme (2015), Oncogene, 34, 1877-1882.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CD95-death-inducing signaling complex
-
Mus musculus
PIDDosome
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
calcium/calmodulin regulated protein kinase II phosphorylates caspase-2 at Ser-135 Mus musculus
coenzyme Q10
-
Mus musculus
cyclin-dependent protein kinase1/cyclin B1
-
Mus musculus
miR-708
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-all-spectrin + H2O Mus musculus
-
?
-
?
BID + H2O Mus musculus
-
?
-
?
caspase-2 + H2O Mus musculus self-cleavage ?
-
?
golgin-160 + H2O Mus musculus
-
?
-
?
mouse double minute 2 homolog + H2O Mus musculus
-
?
-
?
protein kinase Cdelta + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P29594
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein calcium/calmodulin regulated protein kinase II phosphorylates caspase-2 at Ser-135 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-all-spectrin + H2O
-
Mus musculus ?
-
?
BID + H2O
-
Mus musculus ?
-
?
caspase-2 + H2O self-cleavage Mus musculus ?
-
?
golgin-160 + H2O
-
Mus musculus ?
-
?
mouse double minute 2 homolog + H2O
-
Mus musculus ?
-
?
protein kinase Cdelta + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
caspase 2
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is implicated in tumor suppression and plays a role in regulating the cellular response towards oxidative stress. Key cellular processes such as proliferation, aging, maintenance of genome surveillance and the redox system are affected by caspase-2 function Mus musculus