Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CD95-death-inducing signaling complex | - |
Mus musculus | |
PIDDosome | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
calcium/calmodulin regulated protein kinase II | phosphorylates caspase-2 at Ser-135 | Mus musculus | |
coenzyme Q10 | - |
Mus musculus | |
cyclin-dependent protein kinase1/cyclin B1 | - |
Mus musculus | |
miR-708 | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-all-spectrin + H2O | Mus musculus | - |
? | - |
? | |
BID + H2O | Mus musculus | - |
? | - |
? | |
caspase-2 + H2O | Mus musculus | self-cleavage | ? | - |
? | |
golgin-160 + H2O | Mus musculus | - |
? | - |
? | |
mouse double minute 2 homolog + H2O | Mus musculus | - |
? | - |
? | |
protein kinase Cdelta + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P29594 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | calcium/calmodulin regulated protein kinase II phosphorylates caspase-2 at Ser-135 | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-all-spectrin + H2O | - |
Mus musculus | ? | - |
? | |
BID + H2O | - |
Mus musculus | ? | - |
? | |
caspase-2 + H2O | self-cleavage | Mus musculus | ? | - |
? | |
golgin-160 + H2O | - |
Mus musculus | ? | - |
? | |
mouse double minute 2 homolog + H2O | - |
Mus musculus | ? | - |
? | |
protein kinase Cdelta + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
caspase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is implicated in tumor suppression and plays a role in regulating the cellular response towards oxidative stress. Key cellular processes such as proliferation, aging, maintenance of genome surveillance and the redox system are affected by caspase-2 function | Mus musculus |