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Literature summary for 3.4.22.55 extracted from
- Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice (2012), J. Biol. Chem., 287, 14792-14802.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C320A | catalytically inactive | Mus musculus |
| S139An | expression of mutant S139A leads to significantly enhanced growth rate of cells | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P29594 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MEF cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Casp2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | caspase-2 is involved in apoptosis, nuclear factor-kappaB regulation, and tumor suppression. Caspase-2 catalytic site Cys-320 and Ser-139 residues are required for caspase-2 to suppress tumorigenesis in nude mice | Mus musculus |
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Release 2023.1 (January 2023)
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