Cloned (Comment) | Organism |
---|---|
GST-fusion contruct expressed in Escherichia coli BL21 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C320A | catalytic residue, inactive mutant enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-Val-Asp-Val-Ala-Asp-fluoromethylketone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Val-Asp-Val-Ala-Asp-4-nitroanilide + H2O | - |
Homo sapiens | acetyl-Val-Asp-Val-Ala-Asp + 4-nitroaniline | - |
? | |
NF kappaB activator + H2O | RIP1 | Homo sapiens | ? | proteolytic fragments of approximate 56 kDa and 20 kDa | ? |
Synonyms | Comment | Organism |
---|---|---|
caspase 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase 2 represses transcription of the survivin gene, a general regulator of cell division and cytoprotection in tumors. This pathway involves caspase 2 proteolytic cleavage of the nuclearfactor kappaB (NFkappaB) activator, RIP1. Loss of RIP1 abolishes transcription of NFkappaB target genes, including survivin, resulting in deregulated mitotic transitions, enhanced apoptosis and suppression of tumorigenicityin vivo. Caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival. | Homo sapiens |