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Literature summary for 3.4.22.55 extracted from
- Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway (2004), J. Biol. Chem., 279, 35047-35052.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | siRNA directed at caspase-2, inhibits TRAIL-induced cell death | Homo sapiens | |
| z-VDVAD-fmk | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42575 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HCT-116 cell | human colon adenocarcinoma cell | Homo sapiens | - |
| HeLa cell | human cervix adenocarcinoma cell | Homo sapiens | - |
| T3M4 cell | human pancreatic cancer cell | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DEVD-AFC + H2O | - |
Homo sapiens | DEVD + AFC | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-2 | - |
Homo sapiens |
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