Literature summary for 3.4.22.55 extracted from

Li, H.; Bergeron, L.; Cryns, V.; Pasternack, M.S.; Zhu, H.; Shi, L.; Greenberg, A.; Yuan, J.
Activation of caspase-2 in apoptosis (1997), J. Biol. Chem., 272, 21010-21017.

Search for more literature for 3.4.22.55

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme is activated during apoptosis by a caspase-3 (CPP32)-like protease. When cells are induced to undergo apoptosis, endogenous caspase-2 is first cleaved into three fragments of 32000-33000 Da and 14000 Da, which are then further processed into 18000 Da and 12000 Da active subunits	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the enzyme is activated during apoptosis by a caspase-3 (CPP32)-like protease. When cells are induced to undergo apoptosis, endogenous caspase-2 is first cleaved into three fragments of 32000-33000 Da and 14000 Da, which are then further processed into 18000 Da and 12000 Da active subunits	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
JURKAT cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)