Crystallization (Comment) | Organism |
---|---|
hanging-drop vapor diffusion method at 22°C, structures of calpain-3 Protease core mutant-C129S, calpain-3 protease core in complex with E-64, calpain-3 protease core in complex with leupeptin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E-64 | - |
Homo sapiens | |
leupeptin | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P20807 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | insertion sequence IS1 interrupts the protease core and must be cleaved for activation and substrate binding | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | limb-girdle muscular dystrophy type 2a arises from mutations in the Ca+-activated intracellular cysteine protease calpain-3 | Homo sapiens |