Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calpain 3 is a calcium-dependent cysteine protease | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
myoblast | - |
Mus musculus | - |
myotube | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MyoD + H2O | calpain 3 down-regulates MyoD protein levels | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calpain 3 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | reserve cells express higher levels of endogenous Capn3 mRNA than proliferating myoblasts | up |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain 3 is involved in the myogenic differentiation process, calpain 3 participates in the establishment of the pool of reserve cells by decreasing the transcriptional activity of the key myogenic regulator MyoD via proteolysis independently of the ubiquitin-proteasome degradation pathway | Mus musculus |