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Literature summary for 3.4.22.54 extracted from

  • Duguez, S.; Bartoli, M.; Richard, I.
    Calpain 3: a key regulator of the sarcomere? (2006), FEBS J., 273, 3427-3436.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
94000
-
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens loss-of-function mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A. Through the absence of cleavage of the cytoskeletal proteins, calpain 3 deficiency leads to abnormal sarcomers, impairment of muscle contractile capacity and death of muscle fibers ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle fast-twitch and slow-twitch fibers. In this tissue, calpain 3 localizes at several regions of the sarcomere through binding to the giant protein, titin Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ezrin + H2O
-
Homo sapiens ?
-
?
filamin C + H2O
-
Homo sapiens ?
-
?
additional information loss-of-function mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A. Through the absence of cleavage of the cytoskeletal proteins, calpain 3 deficiency leads to abnormal sarcomers, impairment of muscle contractile capacity and death of muscle fibers Homo sapiens ?
-
?
additional information cytoskeletal proteins are one class of its substrates Homo sapiens ?
-
?
talin + H2O
-
Homo sapiens ?
-
?
titin + H2O
-
Homo sapiens ?
-
?
vinexin + H2O
-
Homo sapiens ?
-
?