Application | Comment | Organism |
---|---|---|
medicine | calpain 2 represents a potential therapeutic target in breast cancer | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
x * 80000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AC2M2 cell | - |
Mus musculus | - |
breast cancer cell | - |
Mus musculus | - |
mammary carcinoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 80000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
calpain 2 | - |
Mus musculus |
CAPN2 | - |
Mus musculus |
m-calpain | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | calpain 2 knockdown in breast cancer cells correlates with reduced in vitro proliferation, migration, and in vivo tumorigenicity as well as reduced Akt activation, increased nuclear FoxO localization, and increased p27Kip1 expression | Mus musculus |
physiological function | calpain 2 promotes proliferation of cancer cells through Akt-FoxO-p27Kip1 signaling | Mus musculus |