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Literature summary for 3.4.22.53 extracted from
- Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria (2009), Biochim. Biophys. Acta, 1793, 1848-1859.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EGTA | - |
Rattus norvegicus |  |
| PD150606 | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the Ca2+ dependency of mitochondrial m-calpain is similar to that of cytosolic m-calpain, 1 mM Ca2+ activates. | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79920 | - |
m-calpain large subunit, calculated from amino acid sequence | Rattus norvegicus |
| 80000 | - |
1 * 80000 + 1 * ?, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE-Sepharose column chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| voltage-dependent anion channel + H2O | mitochondrial m-calpain truncates voltage-dependent anion channel in Ca2+-dependent manner | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 80000 + 1 * ?, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calpain 2 | - |
Rattus norvegicus |
| mitochondrial m-calpain | m-calpain large subunit | Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria by cleaving voltage-dependent anion channel | Rattus norvegicus |
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