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Literature summary for 3.4.22.53 extracted from

  • Hosfield C.M.; Elce J.S.; Davies P.L.; Jia Z.
    Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation (1999), EMBO J., 18, 6880-6889.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
2.6 A crystal structure of m-calpain that has a C-terminal histidine-tag and a mutation of the active site C105S in the large subunit in the Ca2+-free form Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-binding must induce conformational changes that reorient the protease domains to form a functional active site Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q07009
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