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Literature summary for 3.4.22.52 extracted from
- Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury (2016), Neurobiol. Dis., 93, 121-128 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O35350 | catalytic subunit | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retinal ganglion cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leucine-rich repeat protein phosphatase 1 + H2O | - |
Mus musculus | ? | - |
? |  |
| PH domain + H2O | - |
Mus musculus | ? | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | calpain-1 and calpain-2 play opposite roles in retinal ganglion cell death induced by acute intraocular pressure elevation. Calpain-1 activity supports survival of retinal ganglion cell after intraocular pressure elevation. Calpain-2 activity promotes cell death of retinal ganglion cells after intraocular pressure elevation | Mus musculus |
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Release 2023.1 (January 2023)
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